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Definition of "cell-cycle-specific control" |
a type of control arising in scheduling optimal treatment protocols in the case when treated population is sensitive to the therapy only in chosen phases of its cell cycle. A mathematical model of population dynamics used to solve the problem of such control should be composed of subsystems sensitive and insensitive to the drug. It may be achieved by the use of compartmental models. Typical types of perturbations of the cell cycle considered as cel-cycle-specific control are as follows: cell arrest, cell killing, and alteration of the transit time. They could be applied for representation of cell synchronization, cell destruction, and cell recruitment from the specific phase. |
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